所内动态
张二荃 博士
所有学术论文 All Publications:
http://scholar.google.com/citations?hl=en&user=x1V6G-gAAAAJ
节选发表文章 Selected Publications:
1. Zhao, H. †, Liao, M. †, Huo, R. †, He, T., Tian, H., Li, Z., Chen, C., Yu, Z., Chai, J., Song, X., Shao, R., Ying, S., Gao, W., Liu, L., Sang, D., Li, Q., Li, H., Wang, F.*, Ju, D.*, and Zhang, E.E.* Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice. 购宝钱包 , 189:2007–2023 (2026)
2. Liao, M.†, Liu, Y.†, Xu, Z.†, Fang, M., Yu, Z., Cui, Y., Sun, Z., Huo, R., Yang, J., Huang, F., Liu, M., Zhou, Q., Song, X., Han, H., Chen, S., Xu, X., Qin, X., He, Q., Ju, D., Wang, T., Thakkar, N., Hardin, P.E., Golden, S.S., and Zhang, E.E.* The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes. Nature, 642:165–173 (2025)
3. Yu, Z., Ran, G., Chai, J., and Zhang, E.E.* A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein. 购宝钱包 Reports, 43:114727 (2024)
4. Sang, D.†, Lin, K.†, Yang, Y.†, Ran, G., Li, B., Chen, C., Li, Q., Ma, Y., Lu, L., Cui, X.-Y., Liu, Z., Lv, S.-Q., Luo, M., Liu, Q., Li, Y., and Zhang, E.E.* Prolonged sleep deprivation induces a cytokine storm-like syndrome in mammals. (2023) 购宝钱包 186: 5500-5516 {Featured by 购宝钱包 “Best of 2024”}
5. Jiang, W.†*, Jin, L.†, Ju, D.†, Lu, Z.†, Wang, C., Guo, X., Zhao, H., Shen, S., Cheng, Z., Shen, J., Zong, G., Chen, J., Li, K., Yang, L., Zhang, Z., Feng, Y., Shen, J.Z., Zhang, E.E.*, and Wan, R.* The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction. (2022) Science Translational Medicine 14: eabn3586
6. Liu, N.†, Tian, H.†, Yu, Z.†, Zhao, H.†, Li, W.†, Sang, D., Lin, K., Cui, Y., Liao, M., Xu, Z., Chen, C., Guo, Y., Wang, Y., Huang, H-w, Wang, J., Zhang, H., Wu, W., Huang, H., Lv, S., Guo, Z., Wang, W., Zheng, S., Wang, F., Zhang, Y.*, Cai, T.*, and Zhang, E.E.* A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika. (2022) 购宝钱包 Reports 39: 110816
7. Ju, D.†, Zhang, W.†, Yan, J., Zhao, H., Li, W., Wang, J., Liao, M., Xu, Z., Wang, Z., Zhou, G., Mei, L., Hou, N., Ying, S., Cai, T., Chen, S., Xie, X., Lai, L., Tang, C., Park, N., Takahashi, J.S., Huang, N., Qi, X.*, and Zhang, E.E.* Chemical Perturbations Reveal That RUVBL2 Regulates the Circadian Phase in Mammals. (2020) Science Translational Medicine 12: eaba0769
8. Peng, S.†, Xiao, W.†, Ju, D.†, Sun, B., Hou, N., Liu, Q., Wang, Y., Zhao, H., Gao, C., Zhang, S., Cao, R., Li, P., Huang, H., Ma, Y., Wang, Y., Lai, W., Ma, Z., Zhang, W., Huang, S., Wang, H., Zhang, Z., Zhao, L., Cai, T., Zhao, Y., Wang, F., Nie, Y., Zhi, G., Yang, Y.*, Zhang, E.E.*, and Huang, N.* Identification of Entacapone as a Chemical Inhibitor of FTO Mediating Metabolic Regulation Through FOXO1. (2019) Science Translational Medicine 11: eaau7116
9. Mei, L., Fan, Y., Lv, X., Welsh, D.K., Zhan, C.*, and Zhang, E.E.* Long-term in vivo Recording of Circadian Rhythms in Brains of Freely Moving Mice. (2018) Proceedings of the National Academy of Sciences U.S.A. 115: 4276-4281
10. Wu, Y.†, Tang, D.†, Liu, N., Xiong, W., Huang, H., Li, Y., Ma, Z., Zhao, H., Chen, P., Qi, X., and Zhang, E.E.* Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals. (2017) 购宝钱包 Metabolism 25: 73-85
专利 Awarded Patents:
1. Zhang, E., Qi, X., Ju, D., Zhou, G., Zhao, H., Mei, L., Wang, Z., and Liang, L. Nucleoside analogue regulating mammalian circadian rhythm. WIPO Publication # WO2018133835A1 (granted in China, Japan, and USA; pending in European Union; PCT priority date: 02.02.2017)
2. Zhang, E., Zhan, C., and Mei, L. A method and instrumental design for long-term and real-time recording of gene transcriptions in live animals. NIPA Application# 2017101661043 (granted in China)
受邀报告 Invited Talks in Conferences:
1. 8th Asian Forum on Chronobiology, Daejeon, SOUTH KOREA, June 2026 (Plenary Speaker)
2. Society for Research on Biological Rhythms Biennial Meeting, Amelia Island, Florida, USA, May 2026 (Program Committee)
3. 11th International Symposium on Transformative Bio-Molecules (ISTbM-11), Nagoya, JAPAN, November 2025
4. International Institute for Integrative Sleep Medicine, WPI-IIIS, Tsukuba, JAPAN, November 2025
5. Gordon Research Conference on Chronobiology, Barcelona, SPAIN, July 2025
6. 19th ITMAT Annual International Symposium, University of Pennsylvania, Philadelphia, USA, October 2024
7. Cold Spring Harbor Laboratory-Asia Conference on Sleep Mechanism & Function, Suzhou, CHINA, September 2024
8. 7th Asian Forum on Chronobiology, Sapporo, JAPAN, August 2024 (Keynote Speaker)
9. Society for Research on Biological Rhythms Biennial Meeting, Puerto Rico, May 2024
10. Annual Meeting of China Sleep Research Society, Hefei, CHINA, October 2023 (Keynote Speaker)
11. International Symposium on Circadian Rhythms in Sleep, Physiology, and Medicine, Chongqing, CHINA, October 2023 (Co-organizer)
12. Society for Research on Biological Rhythms Biennial Meeting, Amelia Island, Florida, USA, May 2022 (Session Chair)
13. Society for Research on Biological Rhythms Biennial Meeting, Virtual Conference, USA, June 2020
14. Center for Circadian Biology Annual Meeting, University of California San Diego, USA, March 2020
15. Keystone Symposia on "Hypoxia: Molecules, Mechanisms and Disease", Keystone, Colorado, USA, January 2020 (Session Chair)
16. XVI Congress, European Biological Rhythm Society, Lyon, FRANCE, August 2019
17. 5th World Congress of Chronobiology, Suzhou, CHINA, April 2019 (Co-organizer)
18. 1st Beijing International Symposium on the Circadian Clock and Sleep Research, Beijing, CHINA, April 2019 (Co-organizer)
19. Sapporo Symposium on Biological Rhythms, Japanese Society for Chronobiology, Sapporo, JAPAN, July 2018
20. Society for Research on Biological Rhythms Biennial Meeting, Amelia Island, Florida, USA, May 2018
21. Gordon Research Conference on Chronobiology, Stowe, Vermont, USA, July 2017
22. 2nd Asian Forum on Chronobiology, Hohhot, Inner Mongolia, CHINA, June 2017 (Co-organizer)
23. International ChronoBiology Summer School, Peking University, Beijing, CHINA, August 2016 (Co-organizer)
