发表文章

Publications

1. Scherer, PC., Ding, Y., Liu, Z., Xu, J., Haibin, Moa., Barrow, JC., Ning, W., Zheng, N., Snyder, SH., Rao F. Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Proc. Natl. Acad. Sci. 2016 Early Edition (doi: 10.1073/pnas.1525580113).

2. Rao F. #, Xu, J. #, Fu, C., Cha, J., Xu, R., Gadalla, MM., Wu, M., Fiedler, D., Barrow, JC., Snyder, SH. Inositol pyrophosphates promote cancer growth and metastasis by antagonizing the tumor suppressor LKB1. Proc. Natl. Acad. Sci. 2015 112, 1773-8 (#= Co-first author).
3. Rao F. #, Xu, J. #, Kahn, AB., Cha, J., Xu, R. Tyagi, R., Dang, Y., Chakraborty, A., Snyder, SH. Inositol hexakisphosphate kinase-1 mediates assembly/ disassembly of the CRL4-Signalosome complex to regulate DNA repair and 购宝钱包 death. Proc. Natl. Acad. Sci. 2014 111, 16005-16010. (#= Co-first author).
4. Rao F., Cha, J., Xu, J., Xu, R., Vandiver, MS., Tokhunt, RT., Wu, M., Fiedler, D., Barrow, J., Snyder, SH. Inositol pyrophosphates mediate the DNA-PK/ATM-p53 购宝钱包 death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol. 购宝钱包 2014 54, 119-32.
5. Rao, F., See, RY., Zhang, D., Toh, DC., Liang Z-X. YybT is a signaling protein that contains a cyclic-di-nucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. J. Biol. Chem. 2010, 285:473-82.
6. Tan E#., Rao F#., Pasunooti S., Pham TH., Soehano I., Turner MS., Liew CW., Lescar J., Pervushin K., Liang Z-X.  Solution structure of the PAS domain of a thermophilic YybT homolog reveals a potential ligand-binding site. J. Biol. Chem. 2013, 288:11949-59. (#= Co-first author).
7. Rao, F.*, Qi, Y., Murugan, E., Pasunooti, S., Ji, Q. 2’,3’-cAMP hydrolysis by metal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: implications for PDE screening. Biochem. Biophys. Res. Commun. 2010, 398:500-505. (*= Corresponding author)
8. Rao, F., Pasunooti, S., Ng, Y., Zhuo, W., Lim, L., Liu, AW., Liang Z-X. Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase. Anal. Biochem. 2009, 389:138-42.
9. Rao, F., Ji, Q., Soehano, I., Liang, Z-X. Unusual Heme-Binding PAS Domain from YybT Family Proteins. J. Bacteriol. 2011, 193:1543-1551.
10. Rao, F., Qi, Y., Chong, HS., Kotaka, M., Li, B., Lescar, J., Tang, K., Liang, Z-X. The functional role of a conserved loop in EAL domain-based c-di-GMP specific phosphodiesterase. J. Bacteriol. 2009, 191:4722-31
11. Rao, F., Yang, Y., Qi, Y., Liang, Z-X. Catalytic mechanism of C-di-GMP specific phosphodiesterase: a study of the EAL domain containing protein RocR from Psudomonas aeruginosa. J. Bacteriol. 2008, 190:3622-31
12. Rao, F., et al. Hong, Y. Medaka tert produces multiple variants with differential expression during differentiation in vitro and in vivo. Int. J. Biol .Sci. 2011, 7(4):426-439.

Patent
Liang, Z-X., Rao, F. Diguanylate cyclase method of producing the same and its use in the manufacture of cyclic-di-GMP and analogues thereof. 2014, US Patent No:  8,859,237.